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Lamivudine
Catalog NO.: API-001
| CAS NO.: 134678-17-4 | Brand: BIOCAXIS
Category
Nucleosides & Nucleotides, 2’-deoxy
Synonyms:
Epivir; Zeffix; Heptovir
2′,3′-Dideoxy-3′-thiacytidine,
3TC
Molecular Formula
C8H11N3O3S
Molecular Weight
229.26
General description
Lamivudine (BCH-189) is an
orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can
inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of
hepatitis B virus. Lamivudine salicylate can penetrate the CNS.
Lamivudine has been used to deplete the
Hepatitis B Virus (HBV) covalently closed circular DNA (cccDNA) forms for the
preparation of inverse nested PCR.
Biochem/physiol Actions
Lamivudine is a potent
nucleoside analog reverse transcriptase inhibitor (nRTI).
Lamivudine is a potent
nucleoside analog reverse transcriptase inhibitor (nRTI). It is an analogue of
cytidine, and can inhibit both types (1 and 2) of HIV reverse transcriptase as
well as the reverse transcriptase of hepatitis B. It needs to be phosphorylated
to its triphosphate form before it is active. 3TC-triphosphate also inhibits
cellular DNA polymerase.
Lamivudine, a synthetic nucleoside analogue, plays a role
in the study of viral replication mechanisms, particularly within the context
of HIV and Hepatitis B viruses. As a potent inhibitor of reverse transcriptase,
an enzyme pivotal for the transcription of viral RNA into DNA, Lamivudine
integrates into the viral DNA chain during replication. This incorporation
results in chain termination, effectively halting the virus′s
ability to replicate. Its mechanism underscores the dynamic interplay between
viral enzymes and nucleoside analogues, offering a window into understanding
viral resistance and the evolution of antiviral strategies. In research,
Lamivudine serves as a tool to dissect the complexities of viral life cycles,
providing insights into the molecular underpinnings of viral persistence and
the development of resistance, thereby contributing to the broader field of
antiviral drug discovery and the quest for more effective treatments for viral
infections.