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Tenofovir disoproxil
fumarate
Catalog NO.: API-003
| CAS NO.: 202138-50-9 | Brand: BIOCAXIS
Category
Nucleosides & Nucleotides, 2’-deoxy
Synonyms:
Bis(POC)PMPA fumarate, Bis{[(Isopropoxycarbonyl)oxy]methyl}
({[(2R)-1-(6-amino-9H-purin-9-yl)-2-propanyl]oxy}methyl)phosphonate fumarate
Viread; Tenofovir DF;
Bis(POC)-PMPA fumarate; GS 4331 fumarate
Molecular Formula
C19H30N5O10P · C4H4O4
Molecular Weight
635.51
General description
Tenofovir Disoproxil fumarate is
a nucleotide reverse transcriptase inhibitor used to treat HIV and chronic
Hepatitis B.
Tenofovir disoproxil fumarate
(tenofovir DF) is a nucleotide analogue with activity against retroviruses,
such as human immunodeficiency virus (HIV)-1, HIV-2 and hepadnaviruses.[1]
Tenofovir disoproxil fumarate is
a prodrug of tenofovir, a nucleotide analogue reverse transcriptase inhibitor
(nRTI) that causes premature termination of DNA transcription. In a T cell line
and primary blood lymphocytes, the antiviral activity of tenofovir disoproxil
was shown to be more than 100-fold greater than tenofovir because of its rapid
intracellular uptake. Tenofovir disoproxil fumarate has been used alone and in
various combinations for the prevention and treatment of HIV/AIDS and chronic
hepatitis B infections and is on the World Health Organization′s
List of Essential Medicines.
Tenofovir disoproxil fumarate is
a prodrug of tenofovir, a nucleotide analogue reverse transcriptase inhibitor
(nRTI); anti-retroviral.