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β-Nicotinamide Mononucleotide
Catalog NO.: NMP-011 | CAS NO.: 1094-61-7 | Brand: BIOCAXIS
Category
Nucleosides & Nucleotides, Nucleotide
Synonyms:
Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-β-D-ribofuranosyl)-, inner salt; 3-Carbamoyl-1-β-D-ribofuranosylpyridinium hydroxide, 5'-phosphate, inner
salt; Pyridinium, 3-carbamoyl-1-β-D-ribofuranosyl-,
hydroxide, 5'-(dihydrogen phosphate), inner salt; Nicotinamide mononucleotide;
Nicotinamide ribonucleoside 5'-phosphate; Nicotinamide ribonucleotide;
Nicotinamide ribotide; NMN; NMN (mononucleotide);
β-D-NMN; β-NMN
β-NMN, β-Nicotinamide ribose monophosphate, NMN,
Nicotinamide ribotide, Nicotinamide-1-ium-1-β-D-ribofuranoside 5′-phosphate
Molecular Formula
C11H15N2O8P
Molecular Weight
334.22
General description
β-nicotinamide mononucleotide (β-NM) is a product
of the nicotinamide phosphoribosyltransferase (NAMPT)
reaction and a key NAD+ intermediate. The pharmacological activities of
β-nicotinamide mononucleotide include its role in cellular biochemical
functions, cardioprotection, diabetes, Alzheimer's
disease, and complications associated with obesity.
β-Nicotinamide mononucleotide (β-NMN) is an
intermediate in the nicotinamide phosphoribosyltransferase
(NAMPT)-catalyzed biosynthesis of nicotinamide adenine dinucleotide (NAD+).
NAMPT mediates the condensation of nicotinamide with
5-phosphoribosyl-1-pyrophosphate to produce β-NMN. β-NMN adenyltransferase subsequently converts β-NMN to NAD+.
Application
β-Nicotinamide mononucleotide (NMN) is used to study
binding motifs within RNA aptamers and ribozyme activation processes involving
β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments.