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DMT-2′-O-Methyl-rA(bz) Phosphoramidite
Catalog NO.: RNA-OMEPM-001 | CAS NO.: 110782-31-5 | Brand: BIOCAXIS
Category
Carbohydrates, Nucleosides & Nucleotides, RNA
Phosphoramidites
Synonyms:
DMT-2′-O-Me-rA(bz)
amidite, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-adenosine,
3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
Molecular Formula
C48H54N7O8P
Molecular Weight
887.96
General description
Proligo′s 2′O-Methyl RNA monomers are
compatible with fast deprotectionschemes that are based on the application of
aliphatic amines, such asmethylamine. The adenosine and guanosine monomers are
protected bythe standard benzoyl (bz) and isobutyryl (ib) groups.2′O-Methyl
RNA is a nucleic acid analog that is characterized by theexceptional
hybridization properties that it imparts with complimentaryDNA or RNA, as well
as increased stability against enzymatic degradationcompared to natural nucleic
acids.The unique combination of properties of 2′O-Methyl RNA had
foundwidespread use in the fields of:
Diagnostic probes
Aptamer and ribozyme development
Mixed 2′O-Methyl-RNA/DNA antisense molecules
Usage
Solid phase synthesis of DNA and RNA oligonucleotides in
chemical or enzymatic processes.