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DMT-2′-O-Methyl-rC(ac) Phosphoramidite
Catalog NO.: RNA-OMEPM-002 | CAS NO.: 199593-09-4 | Brand: BIOCAXIS
Category
Carbohydrates, Nucleosides & Nucleotides, RNA
Phosphoramidites
Synonyms:
N-acetyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-cytidine,
3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
Molecular Formula
C42H52N5O9P
Molecular Weight
801.86
General description
DMT-2′O-Methyl-rC(ac) Phosphoramidite is a 2′O-Methyl
RNA monomer that is compatible with fast deprotection schemes that are based on
the application of aliphatic amines, such as methylamine. Modern
phosphoramidite mediated synthesis has enabled routine high-yielding
preparations of 2′O-Methyl RNA oligonucleotides. High-quality RNA
phosphoramidites are key to low failure rates, the high biological activity of
synthesis products, and cost-effectiveness. 2′O-Methyl RNA is a nucleic
acid analog that is characterized by the exceptional hybridization properties
that it imparts with complimentary DNA or RNA, as well as increased stability
against enzymatic degradation compared to natural nucleic acids.
Application
2′O-Methyl RNA nucleoside including DMT-2′O-Methyl-rC(ac)
Phosphoramidite can be advantageously incorporated in nucleic acid probes with
RNA or DNA for in-vivo or in-vitro applications to convey nuclease
resistance.The unique combination of properties of 2′O-Methyl RNA had
found widespread use in the fields of:
- Diagnostic
probes
- Aptamer
and ribozyme development
- Mixed
2′O-Methyl-RNA/DNA antisense molecules
Usage
Solid phase synthesis of DNA and RNA oligonucleotides in
chemical or enzymatic processes.