Biocaxis > Products > Nucleoside |
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Cytarabine
Catalog NO.: NS-005
| CAS NO.: 147-94-4 |
Brand: BIOCAXIS
Category
Nucleosides & Nucleotides, nucleobase
Synonyms:
(β-D-Arabinofuranosyl)cytosine,
Ara-C, Arabinocytidine, Arabinosylcytosine,
Cytarabine, Cytosine arabinoside
Molecular Formula
C9H13N3O5
Molecular Weight
243.22
General description
Cytarabine, a nucleoside analog, causes S phase cell cycle
arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an
IC50 of 16 nM. Cytarabine has antiviral effects
against HSV. Cytarabine shows anti-orthopoxvirus
activity.
Ara-C incorporates into DNA and inhibits DNA replication by
forming cleavage complexes with topoisomerase I resulting in DNA fragmentation;
does not inhibit RNA synthesis. Anti-leukemia agent.