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Polyinosinic acid tripotassium salt

Catalog NO.: OLIG-004 | CAS NO.: 26936-41-4 | Brand: BIOCAXIS

Category

Nucleosides & Nucleotides, oligo

Synonyms:

Poly(I); Polyinosinylic acid

Poly(I) potassium salt

Molecular Formula

(C₁₀H₁₃N₄O₈P)x.xK

Molecular Weight

General description

Polyinosinic acid tripotassium salt (PITP) is a potent inhibitor of the replication of human cytomegalovirus (HCMV) in cell culture. PITP is an antiviral compound that binds to the virus and inhibits its ability to replicate by preventing the phosphatase activity required for viral DNA synthesis. PITP has been shown to inhibit tumor growth in animal models and is being investigated as a potential therapeutic agent for bladder cancer. PITP may be used as a diagnostic tool for bladder cancer because it can be detected in urine samples and is not found in normal urine.

Polyinosinic acid potassium salt is a synthetic polynucleotide composed of repeating units of inosinic acid connected by phosphate linkages. It is referred to as poly(I). It is primarily employed in the field of molecular biology and genetics. It serves as useful for studying nucleic acid-protein interactions, RNA splicing, translation initiation, and other cellular processes. Its ability to bind specifically to RNA and DNA molecules makes it a versatile reagent for investigating nucleic acid structure, function, and interactions. One of the significant scientific applications of polyinosinic acid potassium salt is its utilization as an adjuvant in immunology research. Adjuvants are substances that enhance the immune response to antigens. Polyinosinic acid potassium salt can stimulate the immune system by activating toll-like receptors (TLRs), specifically TLR3, which plays a role in recognizing viral RNA. Activation of TLR3 leads to the production of pro-inflammatory cytokines and the initiation of an immune response. Furthermore, polyinosinic acid potassium salt is involved in the study of viral infections and antiviral defense mechanisms. It can mimic double-stranded RNA (dsRNA), which is a common viral component, thereby triggering the innate immune response and the production of interferons. This property allows researchers to investigate the mechanisms by which cells detect and respond to viral infections. In terms of its mechanisms of action, polyinosinic acid potassium salt acts as a ligand for TLR3, a receptor found on various immune cells. Upon binding to TLR3, it activates downstream signaling pathways that lead to the production of inflammatory cytokines, interferons, and other immune mediators. This activation ultimately enhances the immune response, contributing to the clearance of pathogens and the development of adaptive immunity.

Polyinosinic acid (Poly(I)) is a homopolymer of inosine that may be used with polycytidylic acid (poly(C)) to form the double-stranded homopolymer (Poly(I) • Poly(C)). TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. (Poly(I) • Poly(C)) is a used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.

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