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ε-Polylysine

Introduction:
ε-Polylysine, a kind of peptide with a linkage between a－carboxyl group and e－amino group, is a natural substance from microbial metabolism. It has lots of advantages over traditional preservatives, such as high safety good heat tolerance and solubility in water and extensive antimicrobial against Gram+ bacteria and fungi. Now it has been applied extensively in food and pharmaceutical industry for the wide range of antimicrobial spectrum.

Physical properties:
ε-Polylysine is the polymer of L-lysine. It is slightly bitter, hygroscopic, light yellow power. It is soluble in water, slightly soluble in ethanol. The 30-unit homopolymer has a molecular weight of 4700 and an empirical formula of C180H362N60O31. It is still stable when heated (120℃，20min or 100℃,30min). It inhibits the thermophilics. So it is also applied to high temperature process. The activity of ε-Polylysine decreases at the presence of acidic polysaccharide, chloride, phosphate, and Cu2+ while its activity increases with presence of hydrochloric acid, citric acid, malic acid, glycine and glyceride.

Molecular formular:



Safety:
ε-Polylysine is recognized as a very safe substance in the scientific community. ε-Polylysine was generally recognized as safe as food preservative by FDA in October, 2003.It had been approved by FDA for use as an antimicrobial agent in cooked rice or sushi rice at levels up to 50 milligrams per kilogram (mg/kg) of rice. The results of an acute toxicity study and bacterial assays for mutagenicity shows that ε-Polylysine was non-toxic and there was no evidence for mutagenic activity of ε-Polylysine. So ε-Polylysine is absolutely safe to be used as food preservative.

Quality Standard:
FAO/WHO， 1992

Application:
ε-Polylysine has already been used generally as a food additive recognized its safety and advantage in Japan and Republic of Korea. Moreover, ε-Polylysine is acknowledged as a world standard food additive by this recognition of ε-Polylysine as a GRAS material of FDA in US.ε-Polylysine has a function to prevent a microbe from proliferating by ionic adsorption in the microbe. By such excellent properties as various antibacterial properties and properties not to destroy flavor, polylysine has been used mainly as what improves in keeping quality of food and applied to a box lunch and prepared foodstuffs in a convenience store or the like.It can be used in rice, noodles, cakes, snacks, and ice creams, salad, canned foods and meat products.
In addition, ε-polylysine is used in SAP to produce sanitation products, such as sanitation napkin and diapers because of its good absorption of liquid. It can also be used as a carrier for pharmaceutical molecules. Moreover, even in a field other than food, taking advantages of characteristics of polylysine ,the application to fiber, processed goods, cosmetics as an antibacterial agent excellent in kitchen and bath room application has also been developed.

Storage:
Be laid in dry,shady and cool place with sealed packing.